The future of Advanced Diagnostics depends on the optical components that make life-changing medical devices possible.
Optical components from Edmund Optics® are used in countless applications to assist in the diagnosis of the brain, eye, and blood including detecting neuronal activity, genetic disorders, or hormone imbalances in the brain, to macular degeneration, diabetic retinopathy, glaucoma, or other retinal disorders in the eye, to tumor immunology, hematology, sperm sorting, or apoptosis in blood. These applications and technologies are as diverse as confocal and multi-photon microscopy, flow cytometry, cell sorting, optical coherence tomography (OCT), and other biomedical applications. EO offers complete product selection to build your own microscope or entire instrumentation sorting platform.
- Single source stock component provider of EO designed and manufactured optical components, imaging lenses, and advanced coatings
- Over 150 engineers with design, manufacturing, and application expertise
- Key products available from industry leading partners such as Mitutoyo, Olympus, Nikon, Coherent®, and Hamamatsu
- ISO9001:2000 and compliance programs designed to meet quality control needs, traceability, and serialization of advanced diagnostics manufacturers
- Website provides easy access to technical content, tools, and over 55,000 downloadable engineering files
Blood | Optics Enabling Flow Cytometry
Blood is the fluid that keeps the human body functioning by delivering essential nutrients and oxygen to cells, while also removing excess nutrients and waste from those same cells. Blood consists of plasma, blood cells, water, proteins, ions, glucose, various hormones, and many other components. Proper maintenance and care is needed to ensure a healthy and long life. Optical systems such as flow cytometers, cell sorters, and optofluidics devices are used to quickly and accurately diagnose a variety of ailments. Laser based scanning flow systems consisting of lenses, filters, prisms, and other optical components can quickly detect abnormalities in red blood cells or white blood cells. Fluorescence based cell sorters also consist of similar optical components and can accurately detect CTCs in a patient, greatly improving their chances of survival.
HIGH THROUGHPUT SCREENING
A powerful technology that analyzes physical and chemical characteristics of particles in a fluid suspension. Qualitative and quantitative data is collected as the particles flow through a laser beam and forward and side scattered light is collected.
Fluorescence activated cell sorting (FACS) is a specific branch of flow cytometry that actively sorts a heterogeneous collection of cells into various containers a single cell at a time. This is done using general light scattering and fluorescence principles based off of each cell’s characteristics.
Technology that combines the field of microfluidics with optics. The primary applications include broad covering liquid displays, energy, and optical lenses, but the primary startup company drive is focusing on lab-on-chip devices, biosensors, and molecular imaging systems.
HIGH THROUGHPUT SCREENING
A powerful drug-discovery process used heavily in pharmaceuticals. Typically an automated procedure that allows for quicker development of novel drugs with less risk for human error.
Neuroscience technique intended to map and list out the specific quantities or properties of the brain in a spatial representation. In other terms, the anatomy and function of the brain, spine, and central nervous system through imaging techniques.
Biological technique that involves the use of light to control cells in living tissue, specifically neurons in most cases that have been genetically modified with photoreceptors that react to different wavebands.
Method of making brain tissue transparent using hydrogels. Accompanied with antibodies or biomarkers, highly detailed pictures of nucleic structure of the brain can be determined and studied.
A genetically encoded calcium indicator used in brain imaging. GCAMP is similar to the fusion of green fluorescent protein (GFP), calmodulin, and a peptide sequence from myosin.
Green fluorescent protein (GFP) is a specialized protein consisting of a specific group of amino acids that glows green when exposed to UV/Blue light. Extracted from marine life, the most common excitation wavelength is 395nm to 475nm with emission peaks from 509nm to 525nm. GFP is widely used in non-invasive fluorescence imaging systems to detect for tumor growth, apoptosis, and other cellular activity.
Branch of medicine that deals with the anatomy, study, and diseases of the eye. The eye is one of the leading indicators for diagnosing a number of serious ailments. Due to the ease of access and high level of transmission, the eye has become the “gold standard” for non-invasive medical imaging through various platforms and technologies such as optical coherence tomography (OCT).
A powerful medical imaging technique utilizing light to capture high resolution, three-dimensional images from optical scatter in biological tissue. The principles are based off of simple interferometry with near infrared (NIR) light to effectively penetrate the biological medium. A trade-off exists between depth penetration and resolution, but OCT is often coupled with other technologies to ensure accuracy and multi-model images.
BIOMETRICES/ PUPIL RECOGNITION
Automated biometric identification using mathematical algorithms to identify and properly recognize an individual’s iris/pupil. This form of biometric recognition is very reliable, as a human’s eye pattern is completely unique, stable over long periods of time, and can be distinguished and recognized over a great distance.
Low power specialty microscope with a camera acting as a functional ophthalmoscope.